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. 2019 Oct 19;2019(10):CD012310. doi: 10.1002/14651858.CD012310.pub2

Maric 2009.

Methods Study design: parallel, randomised, double‐blind, placebo‐controlled clinical trial
 Analysis by ITT: not reported
Participants Country: Croatia
 Centres: not reported
 Recruitment period: not reported
 Follow‐up period: not reported
 Surgery: open abdominal colorectal surgery
 Indication: not reported
 Urgency: elective
 Incision: midline
 Length of incision: not reported
 Exclusion criteria: not reported
Number randomised = 50 (local anaesthetic n = 25; control n = 25)
 Post‐randomisation exclusion: not reported
 Number analysed: not reported
 Demographics: not reported
Interventions Continuous wound infusion with:
  • local anaesthetic: levobupivacaine 0.25% (n = 50)

  • control: NaCl 0.9% (n = 50)


Number of wound catheters: 2
 Length of wound catheter: not reported
 Wound catheter position: suprafascial; 1 catheter placed along on each wound edge
 Infusion rate: 8 mL bolus followed by 8 mL/h total (4 mL bolus followed by 4 mL/h per catheter)
 Infusion duration: 48 h
 
 Intra‐operative analgesic co‐interventions: not reported
Postoperative analgesic co‐interventions
  • IV diclofenac 75 mg 12‐hourly

  • IV morphine via PCA (programme not reported)

Outcomes Outcomes relevant to current review
  • Pain score (presumed at rest, VAS), recorded at 6, 12, 24 and 48 after surgerya

  • Morphine consumption, recorded at 6, 12, 24 and 48 after surgery

  • Nausea and vomitinga

  • “Side effects” (details not reported)a

Notes Currently only available as conference abstract. Contacted trial author on 22 February 2017. Did not receive response.
aResults reported qualitatively only ("Satisfactory analgesia was achieved in both groups... Nausea and vomiting were less present in Group L. No side effects were observed.”).

ITT: intention‐to‐treat; IV: intravenous; PCA: patient‐controlled analgesia; VAS: visual analogue scale