Summary of findings 2. Prophylactic LMWH versus placebo for superficial thrombophlebitis of the leg.
| Prophylactic LMWH versus placebo for superficial thrombophlebitis of the leg | ||||||
| Patient or population: people with ST of the leg Settings: hospitalised and non‐hospitalised Intervention: prophylactic LMWH versus placebo | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Placebo | Prophylactic LMWH | |||||
| Symptomatic VTE Follow‐up: 97 days | 45 per 1000 | 54 per 1000 (17 to 174) | RR 1.22 (0.38 to 3.89) | 222 (1 study) | ⊕⊕⊝⊝ Low1,2 | ‐ |
| Major bleeding Follow‐up: 97 days | See comment | See comment | Not estimable | 222 (1 study) | ⊕⊕⊝⊝ Low1,2 | 0 episodes of major bleeding |
| Extension or recurrence (or both) of ST Follow‐up: 97 days | 330 per 1000 | 145 per 1000 (86 to 244) | RR 0.44 (0.26 to 0.74) | 222 (1 study) | ⊕⊕⊝⊝ Low1,2 | ‐ |
| Mortality | See comment | See comment | See comment | ‐ | See comment | Data not available |
| Minor bleeding | See comment | See comment | See comment | ‐ | See comment | Data not available |
| Adverse effects of treatment | See comment | See comment | See comment | ‐ | See comment | Data not available |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; LMWH: low molecular weight heparin; RR: risk ratio; ST: superficial thrombophlebitis; VTE: venous thromboembolism. | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1Evidence downgraded one level due to unclear random sequence generation and incomplete outcome data. 2Evidence downgraded one level for imprecision due to a low number of events.