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. 2018 Feb 25;2018(2):CD004982. doi: 10.1002/14651858.CD004982.pub6

Boehler 2014.

Methods Prospective, single‐centre, open‐label, randomised study.
Participants 73 outpatients with isolated superficial vein thrombosis of the legs. Thrombus length ≥ 5 cm and confirmed by compression ultrasonography. Mean age 56.3 years (SD 13.2) in compression stockings group and 60.3 years (SD 14.8) in control group.
Interventions Thigh‐length compression stockings, class II (23‐32 mmHg; Venotrain, Bauerfeind, Zeulenroda, Germany) for 3 weeks.
No compression.
Outcomes Primary outcome: reduction of spontaneous and induced pain as assessed by a VAS and Lowenberg test.
Secondary outcomes: consumption of analgesics, thrombus length, skin erythema, D‐dimer, and quality of life through the SF‐36.
Main safety outcomes: symptomatic or asymptomatic DVT and HIT.
Notes All participants received LMWH at prophylactic dosage (enoxaparin 40 mg/day). NSAIDs (mefenamic acid, diclofenac, and dexibuprofen) were allowed.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method of sequence generation not reported. "The randomization procedure was performed in a 1:1 ratio in blocks of 20 with closed envelopes."
Allocation concealment (selection bias) Unclear risk Unclear if envelopes were sealed and sequentially numbered. "The randomization procedure was performed in a 1:1 ratio in blocks of 20 with closed envelopes, with the investigators not being aware of the sequence within the envelopes."
Blinding (performance bias and detection bias) 
 All outcomes High risk Open study.
Incomplete outcome data (attrition bias) 
 All outcomes High risk 7/80 (8.7%) participants initially enrolled were excluded from the analysis due to missing data during follow‐up.
Selective reporting (reporting bias) Low risk All outcomes described in methods section were reported in results section of the study publication.