Holzgreve 1989.

Methods	RCT.
Participants	60 participants with ST of the legs; 17 males, 43 females; mean age 53.4 years (SD 12). Not reported if participants were hospitalised or non‐hospitalised or if diagnosis of ST was objectively confirmed by ultrasonography.
Interventions	Etofenak gel. Diclofenac gel.
Outcomes	Length of superficial venous thrombosis, pain, redness, palpable veins, oedema.
Notes	All participants had compression therapy. Funding: not reported. Disclosure of potential COI: not reported, no COI forms available.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of random sequence generation not reported.
Allocation concealment (selection bias)	Unclear risk	Method of allocation concealment not reported.
Blinding (performance bias and detection bias) All outcomes	High risk	Single‐blinded. Authors stated it was a single‐blind study, and the participants received medication that was labelled as "trial medication." Unclear from paper whether trial physician was blinded to treatment, and since the outcome was symptom improvement, there was a high risk of detection bias by imperfect blinding.
Incomplete outcome data (attrition bias) All outcomes	High risk	20 (33%) participants lost to follow‐up.
Selective reporting (reporting bias)	Low risk	All prespecified outcomes reported.