Hyvernat 2016.

Methods	Randomized controlled trial with 2 parallel groups 4 centres Dates study was conducted: from November 2008 through June 2010
Participants	Adults (n = 120) with septic shock Subgroups based on adrenal status assessed by a 250‐µg ACTH test Setting: intensive care unit Study location: France
Interventions	Hydrocortisone 50 mg intravenous bolus every 6 hours for 5 days without tapering Hydrocortisone as an initial bolus of 100 mg followed by continuous infusion of 300 mg per day for 5 days without tapering
Outcomes	Primary 28‐Day all‐cause mortality Secondary Time Days free of vasopressor (with zero days assigned to participants dying before being weaned off) Days free of mechanical ventilation (with zero days assigned to participants dying before being weaned off) Days free of renal replacement therapy (with zero days assigned to participants dying before being weaned off) Safety
Notes	We contacted study authors and obtained access to individual patient data Fundng source: Association Niçoise de Réanimation Médicale
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomization scheme
Allocation concealment (selection bias)	Low risk	Centralized randomization
Blinding (performance bias and detection bias) All outcomes	Low risk	Participants: yes Caregivers: yes Data collectors: yes Outcome assessors: yes Data analysts: yes
Incomplete outcome data (attrition bias) All outcomes	Low risk	Lost to follow‐up: none
Selective reporting (reporting bias)	Low risk	Access to study protocol excluding reporting bias
Other bias	Low risk	No evidence of other bias