Yildiz 2011.

Methods	Randomized controlled trial on 2 parallel groups 1 centre Dates the study was conducted: April 2005 and May 2008
Participants	Adults (n = 55) with sepsis or septic shock Subgroups based on adrenal status assessed by a 250‐µg ACTH test Setting: intensive care unit and infectious disease department Study location: Turkey
Interventions	Prednisolone (intravenous 3 times a day at 06:00 (10 mg), 14:00 (5 mg), and 22:00 (5 mg) for 10 days) Placebo (normal saline)
Outcomes	Primary 28‐Day mortality from all causes Secondary Reversal of organ failure Length of stay Safety Outcomes were also assessed in relation to adrenal insufficiency
Notes	We contacted study authors, who did not reply Funding source: not declared
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random numbers used
Allocation concealment (selection bias)	Low risk	Randomization list kept by the pharmacist
Blinding (performance bias and detection bias) All outcomes	Low risk	Pharmacist: no Participants: yes Caregivers: yes Data collectors: yes Outcome assessors: yes Data analysts: yes
Incomplete outcome data (attrition bias) All outcomes	Low risk	Lost to follow‐up: none
Selective reporting (reporting bias)	Unclear risk	No information
Other bias	Unclear risk	No information