Comparison 6. Aerobic exercise and strength training versus no training in mitochondrial myopathy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Muscle strength shoulder press ‐ maximum dynamic isotonic voluntary contraction (kg)	1	18	Mean Difference (IV, Fixed, 95% CI)	‐3.00 [‐14.71, 4.71]
2 Muscle strength butterfly ‐ maximum dynamic isotonic voluntary contraction (kg)	1	18	Mean Difference (IV, Fixed, 95% CI)	6.4 [‐2.89, 15.69]
3 Muscle strength biceps curls ‐ maximum isotonic dynamic voluntary contraction (kg)	1	18	Mean Difference (IV, Fixed, 95% CI)	7.3 [‐2.91, 17.51]
4 Work capacity ‐ mean time until exhaustion in cycle test (min)	1	18	Mean Difference (IV, Fixed, 95% CI)	23.7 [2.63, 44.77]
5 Work capacity ‐ mean distance until exhaustion in cycle test (km)	1	18	Mean Difference (IV, Fixed, 95% CI)	9.70 [1.51, 17.89]
6 Work capacity ‐ mean distance walked until exhaustion in shuttle walking test (m)	1	18	Mean Difference (IV, Fixed, 95% CI)	78.0 [‐144.86, 300.86]
7 VO2 max in maximal incremental cycle exercise test (L/min)	1	18	Mean Difference (IV, Fixed, 95% CI)	400.0 [‐61.97, 861.97]
8 Quality of life ‐ NHP 0‐100	1	18	Mean Difference (IV, Fixed, 95% CI)	‐9.8 [‐25.74, 6.14]
9 Myoglobin	1	30	Mean Difference (IV, Fixed, 95% CI)	‐21.0 [‐48.35, 6.35]