Fig. 4.

N, P regions and trimming at the variable heavy chain complementarity determining region VH CDR3. The V-D-J junctional diversity created by P region, exonuclease trimming and N region addition significantly contributes to a large VH CDR3 repertoire. The histograms show the average numbers of N and P nucleotides added at the V-D-J junctions, and the average numbers of nucleotides deleted at the 3′V, 5′D, 3′D and 5′J by exonuclease trimming