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. Author manuscript; available in PMC: 2020 Jan 10.
Published in final edited form as: Immunogenetics. 2011 Dec 27;64(5):337–350. doi: 10.1007/s00251-011-0595-8

Fig. 5.

Fig. 5

CDR3 lengths in VH and VL domains, and amino acid usage observed in the cord blood-derived VH CDR3 regions. a Length distribution of 2,927 unique V-KAPPA CDR3 regions. b Length distribution of 1,193 unique V-LAMBDA CDR3 regions. c Length distribution of 24,188 unique VH CDR3 regions showing the highly diversified CDR3 repertoire with different lengths. d Average values of AA composition calculated for all unique VH CDR3 sequences in percent shows the preferred AA usage. The amino acids are arranged by relative hydrophobicity values as found in Kyte-Doolittle scale (Pommié et al. 2004). e The frequency of individual amino acids at specific positions for the most prevalent VH CDR3 of 2,963 sequences having the length of 13 amino acids (the basic length of CDR3-IMGT) is shown. CDR3 positions are shown according to the IMGT unique numbering (Lefranc et al. 2003)