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. 2020 Jan 8;27(1):41–53.e6. doi: 10.1016/j.chom.2019.11.002

Figure 6.

Figure 6

Model of SteE Action

After translocation, SteE interacts with and is phosphorylated by GSK3. GSK3 in complex with phosphorylated SteE then interacts with and phosphorylates STAT3 on Y705. Activated STAT3 drives macrophage polarization.