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. 2020 Jan 8;105(1):122–137.e8. doi: 10.1016/j.neuron.2019.10.011

Figure 1.

Figure 1

Cell-Type-Specific Structural and Functional Constraints

(A) Action potential (AP) whisker receptive fields (wRFs) were recorded in the vibrissal-related part of rat primary somatosensory cortex (vS1) by deflections of the principal (PW) and of each of its eight surrounding whiskers (SWs).

(B) Intracortical (IC) morphologies of in vivo labeled neurons that are representative for each axo-dendritic cell type in vS1 and for thalamocortical (TC) neurons in the ventral posterior medial nucleus (VPM). Example neurons represent pyramidal neurons in layer 2 (L2PY) (n = 16), layer 3 (L3PY) (n = 30), and layer 4 (L4PY) (n = 7); spiny stellates (L4ss) (n = 22) and star pyramids in layer 4 (L4sp) (n = 15); slender-tufted intratelencephalic (L5IT) (n = 18) and thick-tufted pyramidal tract neurons in layer 5 (L5PT) (n = 37); and corticothalamic (L6CT) (n = 13) and corticocortical neurons in layer 6 (L6CC) (n = 19). A subset of the L6CCs had apical-like dendrites that projected toward the white matter (WM) and was grouped as layer 6 inverted neurons (L6INV) (n = 5). L4ss and L4sp neurons were grouped as layer 4 spiny neurons (L4SP).

(C) Whisker RFs averaged across neurons of the same axo-dendritic cell type (L2PY [n = 7], L3PY [n = 7], L4SP [n = 8], L4PY [n = 2], L5IT [n = 13], L5PT [n = 9], L6CT [n = 5], L6CC [n = 6], and L6INV [n = 1]). Whisker RFs of VPM neurons were adopted from Brecht and Sakmann (2002).

See also Figure S1.