Table 2. Clinical characteristics of NSCLC patients with EGFR-TKI sensitizing mutation.
| Variable | EGFR wild type (n=164) | EGFR mutant type (n=66) | p-value |
|---|---|---|---|
| Age (yr) | 66.1±0.78 | 62.4±1.16 | 0.012 |
| Sex | <0.001 | ||
| Male | 116 (70.7) | 22 (33.3) | |
| Female | 48 (29.3) | 44 (66.7) | |
| Smoking history | <0.001 | ||
| Never smoker | 59 (36.0) | 47 (71.2) | |
| Ex-smoker | 46 (28.0) | 7 (10.6) | |
| Current smoker | 59 (36.0) | 12 (18.2) | |
| Histologic type | 0.002* | ||
| Adenocarcinoma | 130 (80.2) | 64 (97.0) | |
| Squamous cell carcinoma | 30 (18.5) | 2 (3.0) | |
| Others | 2 (1.2) | 0 (0) | |
| Stage | 0.133 | ||
| I | 13 (7.9) | 10 (15.2) | |
| II | 7 (4.3) | 2 (3.0) | |
| III | 31 (18.9) | 6 (9.1) | |
| IV | 113 (68.9) | 48 (72.7) | |
| PD-L1 expression (22C3) | 0.156 | ||
| <1% | 61 (37.2) | 30 (45.5) | |
| ≥1% | 103 (62.8) | 36 (54.5) |
Values are presented as mean±SD or number (%).
*Fisher's exact test.
NSCLC: non-small cell lung cancer; EGFR: epidermal growth factor receptor; TKI: tyrosine kinase inhibitor; PD-L1: programmed death-ligand 1.