Table 1.

FRAX-based intervention thresholds recommended/used in Asia.

Country/region	Age-dependent ITs	Major osteoporotic fracture IT (fixed)	Hip fracture IT (fixed)	References
China	–	4.0%	1.3%	32
Hong Kong	–	9.95%	–	33
India	2.8%–17% (major fracture)	–		28
Japan	5%–20% (major fracture)	15%, 10.5%	–	34–36
Malaysia	–	NOF cutoff values	NOF cutoff values	37
Philippines	–	NOF cutoff values	NOF cutoff values	38
Singaporea	2.9%–28% (major) 0.6%–1.4% (hip)	4%	1%	27
Sri Lanka	2.7%–18.6% (major) 0.4%–7.1% (hip)	9%	3%	24
	b15%–18.6% for major and 4.7%–7.1% for hip fracture for 70 and above)	6% (below 70 yr)	2% (below 70 yr)
	–	c6% (below 70 yr)	2% (below 70 yr)
	–	12% (70 and above)	5% (70 and above)
Taiwan		15%	7%	29
Thailand		–	3%	40

FRAX, fracture risk assessment tool; IT, intervention threshold; NOF, National Osteoporosis Foundation.

^aMean weighted values adjusted for population composition.

^bHybrid intervention thresholds.

^cTwo-tier intervention thresholds.