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. 2020 Jan 7;12:100242. doi: 10.1016/j.bonr.2020.100242

Fig. 4.

Fig. 4

Neonatal murine bone marrow transplantation corrects the pathology in NSG oc/oc mice. a MicroCT analysis of the femur of untreated NSG and NSG oc/oc mice, and murine BM-transplanted NSG and NSG oc/oc mice (n = 3 in all groups but transplanted NSG, where n = 2). b Representative images of decalcified formalin-fixed paraffin-embedded vertebral sections of transplanted (tx) NSG and NSG oc/oc mice 3 weeks after transplantation, stained with H/E. Scale bar: 500 μm. c Calcium and phosphorus serum levels in NSG and NSG oc/oc mice 3 weeks after transplantation (n = 2 per genotype; bars indicate the range). d Representative images of spleen of tx NSG and tx NSG oc/oc mice 3 weeks after transplantation, stained with H/E, anti-mouse CD3 or anti-mouse B220 antibody. Scale bar: 500 μm. e Growth curve of NSG and NSG oc/oc mice after transplantation, during the 3-month follow-up. f Representative images of decalcified formalin-fixed paraffin-embedded vertebral sections of transplanted (tx) NSG and NSG oc/oc mice 3 months after transplantation, stained with H/E. Scale bar: 500 μm. g Representative images of spleen of tx NSG and tx NSG oc/oc mice 3 months after transplantation, stained with H/E, anti-mouse CD3 or anti-mouse B220 antibody. Scale bar: 500 μm. h Histograms from FACS analysis of bone marrow (BM) and spleen (SP) cell suspensions from NSG and NSG oc/oc mice 3 months after transplantation (n = 3 per genotype).