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. Author manuscript; available in PMC: 2020 May 18.
Published in final edited form as: Nat Microbiol. 2019 Nov 18;5(1):67–75. doi: 10.1038/s41564-019-0604-5

Extended Data Fig. 9. Pharmacokinetic analysis of Debio-1452-NH3.

Extended Data Fig. 9.

C57/BL6 mice were treated with 50 mg/kg Debio-1452-NH3 via intraperitoneal injection, with three mice per time point (0, 15, 30, 45, 60, 120, 240 480, 960, and 1440 min). After the indicated time points, mice were sacrificed and the serum concentrations of Debio-1452-NH3 were determined by LC-MS/MS. Data are shown mean and represent the average of three independent experiments. The pharmacokinetic parameters shown in the figure above were calculated with a one-compartment model using a nonlinear regression program (Phoenix WinNonlin Version 8.1, Certara USA Inc., Princeton, NJ 08540 USA).