Table 1. Antimicrobial activity of Debio-1452 and derivatives.
Bacterial Strain | MIC (μg/mL) | ||
---|---|---|---|
Debio-1452 | Debio-1452-NH3 | 8 | |
WT Gram-positive | |||
S. aureus ATCC29213 | 0.008 | 0.03 | 0.016 |
Gram-negative permeability mutant | |||
E. coli ΔtolC JW5503 | 0.031 | 0.062 | 0.125 |
E. coli ΔrfaC JW3596 | 0.5 | 0.25 | 0.25 |
WT Gram-negative | |||
E. coli MG1655 | >32 | 4 | >32 |
E. coli BAA-2340 | >32 | 4 | >32 |
E. coli AR-0493 | >32 | 4 | >32 |
E. cloacae ATCC 29893 | >32 | 8 | >32 |
K. pneumoniae BAA-1705 | >32 | 8 | >32 |
K. pneumoniae S47889 | >32 | 8 | >32 |
A. baumannii W41979 | >32 | 4 | >32 |
A. baumannii F19521 | >32 | 4 | >32 |
P. aeruginosa PA01 | >32 | >64 | >32 |