Table 3.

Contributions to variance in the rate of global cognitive decline from demographics, neuropathologic indices, and brain volumetric measures

Variables	Model Identifiers
	Ref	1	2	3
Time	−0.100 (0.004)e	−0.108 (0.005)e	0.002 (0.009)	−0.018 (0.009)a
Age		0.001 (0.001)	0.002 (0.001)d	0.003 (0.001)e
Sex		0.024 (0.010)b	0.009 (0.008)	−0.006 (0.008)
Education		0.003 (0.001)c	0.002 (0.001)b	0.002 (0.001)b
AD Pathology			−0.068 (0.006)e	−0.058 (0.006)e
Gross Infarcts			−0.029 (0.008)d	−0.027 (0.008)d
Lewy Bodies			−0.026 (0.009)c	−0.025 (0.008)c
Hippocampal Sclerosis			−0.058 (0.012)e	−0.040 (0.012)d
TDP-43			−0.009 (0.004)c	−0.006 (0.004)a
Arteriolosclerosis			−0.019 (0.005)e	−0.015 (0.005)d
Hippocampal Volume				0.061 (0.010)e
% of Variance Accounted for by All Effects	-	3.4%	42.6%	48.0%
% of Variance Accounted for by Effects in Boldface Only	-	3.4%	39.2%	5.4%
Model for Comparison	-	Ref	1	2

^ap < 0.1,

^bp < 0.05,

^cp < 0.01,

^dp < 0.001,

^ep < 0.0001