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Rescue of Scn8aN1768D mice by GS967/Prax330. The polycyclic drug GS967/Prax330 18 was incorporated into pelleted food and fed to the heterozygous mutant mice from the age of 1.5 months (pre-seizure onset) to 6 months. The mice were protected against seizures and neurotoxicity until removal of the drug19. p<0.0001 (Log rank). Disease penetrance was higher than in Figure 2; this represents experimental variability within the same mouse line.
