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. Author manuscript; available in PMC: 2020 Jan 10.
Published in final edited form as: Neurobiol Aging. 2017 Oct 13;62:243.e7–243.e14. doi: 10.1016/j.neurobiolaging.2017.09.033

Fig. 3.

Fig. 3.

Mendelian randomization analysis of the effect of plasma homocysteine on AD risk using individual participant data (plasma homocysteine polygenic score association study). Estimates for the effect of 1-standard deviation increase in plasma homocysteine polygenic score on AD risk (OR and 95% CI) while accounting for the effects of age, sex, and APOE ε4 allele status are demonstrated for each study/imputation batch (dark blue). The overall result from the mega-analysis is shown in black. Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; CN, cognitively normal; OR, odds ratio.