Fig. 4.

Effect of plasma homocysteine polygenic score on gray matter atrophy in cognitively normal elderly. (A) Results for whole-brain voxel-based morphometry of the effect of plasma homocysteine polygenic score on gray matter atrophy in 605 cognitively normal elderly depicted in the Montreal Neurological Institute (MNI) space. Significant voxels are shown in blue (threshold-free cluster enhancement, family-wise error corrected p < 0.05). (B) Bivariate correlations between average gray matter volume fraction in the significant voxels shown in (A) and plasma homocysteine polygenic score in each individual. Abbreviation: ROI, region of interest.