Table 2.

Estimates for LoA by onset group, and for loss of function of FARS E Items (for onset <15y). Items are arranged by median duration, including to the analysis of diagnosis of FRDA.

Onset subgroup	Item	Description	Median duration [y]	25, 75 percentiles	N	Observed events	Left censored [%]	Truncation biasa [y]
Loss of ambulation, stratified by onset group
<15y	E7	LoA/gait	11.5	8.6, 16.2	703	148	33	2.9
15–24y	E7	LoA/gait	18.3	14.1, 27.5	211	45	25	7.0
>24y	E7	LoA/gait	23.5	18.0, 30.1	107	21	17	4.7
Loss of stance functions in the FARS E sub score, early onset group (<15y)
<15y	E5	Stance dominant foot	0.2	0.2, 0.2	703	14	97	7.3
<15y	E4	Stance, tandem	0.9	0.2, 2.0	703	46	92	4.8
<15y	E3B	Stance feet together, eyes closed	1.2	0.5, 1.5	703	40	93	2.9
<15y	–	Diagnosis of FRDA	3.0	1.0, 5.0	703	688	2	–
<15y	E2B	Stance feet apart, eyes closed	4.1	2.5, 6.1	703	151	68	2.2
<15y	E3A	Stance, feet together	5.8	3.6, 8.7	703	174	58	2.4
<15y	E2A	Stance, feet apart	9.3	6.7, 12.2	703	180	39	1.5
<15y	FDS	Disease stage	11.1	8.7, 15.6	703	149	33	3.3
<15y	E7	LoA/gait	11.5	8.6, 16.2	703	148	33	2.9

^aDifference between analyses all item-results were floored, e.g. 2.33 or 2.66 were set to 2; the highest number indicates maximum disability (‘unable’).