Skip to main content
. Author manuscript; available in PMC: 2020 Jan 10.
Published in final edited form as: Curr Biol. 2018 May 21;28(10):R589–R590. doi: 10.1016/j.cub.2018.02.064

Figure 1. Satellite cell self-renewal and commitment are critical for muscle regeneration.

Figure 1.

Regeneration is impaired during age and disease due to altered cell signalling and changes to the satellite cell niche. In Duchenne muscular dystrophy (DMD), loss of dystrophin protein results in myofiber fragility and constant damage in DMD muscle. This results in increased numbers of satellite cells that inefficiently differentiate, resulting eventually in satellite cell exhaustion. With age, accumulation of DNA damage, altered niche signalling and an increasingly stiff myofiber results in precocious myogenic commitment as well as cellular senescence. The resulting muscle has an inability to repair due to exhaustion of the satellite cell pool.