Skip to main content
. Author manuscript; available in PMC: 2020 Dec 12.
Published in final edited form as: Exp Gerontol. 2019 Dec 13;131:110767. doi: 10.1016/j.exger.2019.110767

Figure 3: NRF2KO neurons have impaired mitochondrial function.

Figure 3:

Hippocampal neurons isolated from NRF2KO mice grown in culture for 7 days have (A) an altered bioenergetic profile relative to WT neurons with (B) impaired basal and maximal (FCCP-stimulated) respiration as well as spare capacity. n=16–20 wells per genotype. (C) NRF2 neurons also have reduced ATP content and (D) diminished expression of genes encoding enzymes in the ETC. n=12–16 wells per genotype, across 4 experiments *p<0.05, **p<0.01