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. Author manuscript; available in PMC: 2020 Dec 12.
Published in final edited form as: Exp Gerontol. 2019 Dec 13;131:110767. doi: 10.1016/j.exger.2019.110767

Figure 6: Aged NRF2KO mice have impaired hippocampal mitochondria function.

Figure 6:

(A) Isolated hippocampal mitochondria from aged NRF2KO animals show an altered bioenergetic profile relative to mitochondria isolated from aged WT mice. Young mice showed increased oxygen consumption relative to aged mice regardless of sex and genotype. (B) Significant reductions in basal and ADP stimulated respiration as well as (C) respiratory control ratio (RCR) were apparent in hippocampal mitochondria from both aged male and female NRF2KO mice. These parameters were all reduced in aged mice relative to young mice but there was no difference between WT and NRF2KO mice at the young age n=5–8 of each gender per genotype. *p<0.05, pairs of letters indicate statistical significance p<0.001