Fig 9. IL18 expression in hen ovary with and without tumors.

(A) normal ovary with no stain in stroma but abundant surface epithelium stain (arrow); (B) higher magnification of A showing cytoplasmic cell staining in surface epithelium of normal ovary (arrow); (C) IL18 is expressed in cords of tumor cells (arrows); (D) higher magnification shows staining is primarily cytoplasmic (white arrow) and along cell surfaces (black arrow and inset); (E) (left panel) blood vessel with stained immune cells (arrow) and unstained nucleated red blood cells and (right panel) higher magnification of same area; (F) some tumor areas have extracellular (presumably secreted) IL18 which appears as aggregates and single points in extracellular spaces (black arrows) as shown at higher magnification inset. Original magnification: (A) 10X; (B) 40X; (C) 10X; (D) 40X; (E) 4X, left, 40X, right; (F) 4X [inset, 40X].