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Structure of eDHFR PET Reporter Protein, TMP, and [18F]-TMP
(A) Bacterial DHFR complexed with NADPH and TMP (PDB: 3FRE).38 (B) Structures of TMP and [18F]-TMP. (C) Triple reporter plasmid in pELPS with eDHFR (PET reporter gene) fused to yellow fluorescent protein (YFP) and a T2A cleavage site followed by Renilla luciferase, and CAR plasmid pELPS with GD2-scFv-CD8 hinge 4-1BB-CD3z and a T2A cleavage site followed by mCherry selection marker.
