Table 2.
Exposure-response relationships with TCE exposure for miRNAs that showed significant differences between exposed workers and unexposed controls
| No. | miRNA | Controls (n=90) | TCE-exposed | Low-exposed (<12 ppm) (n= 40) | High-exposed (≥12 ppm) (n=34) | Ptrendb | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meana | SDa | Meana | SDa | % difference | P | FDR | Meana | SDa | % change | Pb | Meana | SDa | % difference | Pb | ||||
| 1 | miR-150–5p | 176.0 | 75.9 | 147.3 | 63.1 | −16% | 0.006 | 0.13 | 153.0 | 56.5 | −13% | 0.19 | 140.5 | 70.3 | −20% | 0.002 | 0.002 | |
| 2 | let-7b-5p | 705.0 | 325.2 | 586.6 | 239.3 | −17% | 0.008 | 0.13 | 563.8 | 226.2 | −20% | 0.01 | 613.6 | 254.5 | −13% | 0.07 | 0.03 | |
| 3 | miR-92a-3p | 2478.1 | 798.7 | 2166.8 | 792.2 | −13% | 0.02 | 0.17 | 2054.6 | 861.7 | −17% | 0.02 | 2298.7 | 690.9 | −7% | 0.22 | 0.09 | |
| 4 | miR-122–5p | 1037.7 | 1177.2 | 576.5 | 610.3 | −44% | 0.03 | 0.17 | 364.9 | 280.4 | −65% | 0.00 | 825.4 | 782.8 | −20% | 0.69 | 0.28 | |
| 5 | let-7g-5p | 67.5 | 36.1 | 59.2 | 26.8 | −12% | 0.03 | 0.17 | 59.8 | 26.5 | −11% | 0.09 | 58.6 | 27.5 | −13% | 0.09 | 0.05 | |
| 6 | miR-20a-5p | 649.8 | 249.9 | 573.4 | 222.1 | −12% | 0.03 | 0.17 | 565.1 | 239.6 | −13% | 0.06 | 583.1 | 202.7 | −10% | 0.14 | 0.07 | |
| 7 | miR-140–5p | 8.7 | 4.5 | 7.6 | 4.7 | −13% | 0.04 | 0.19 | 7.8 | 5.1 | −11% | 0.11 | 7.4 | 4.3 | −15% | 0.11 | 0.06 | |
a
Signals in arbitrary unit (A.U.);
b
Estimated by multiple linear regression model adjusted for age, sex, smoking, alcohol use, and recent infection with each log-transformed miRNA level as dependent variable;
c
false discovery rate;
values <0.20 were considered noteworthy.