Table 1.
Demographic and clinical characteristics.
| Variable | Total (n = 126) | Low BMI (n = 63) | High BMI (n = 63) | P-Value | Effect Sizea |
|---|---|---|---|---|---|
| Age in years, mean ± SD (range) | 74.0 ± 5.9 (63.5 – 89.0) | 74.9 ± 5.9 (65.0 – 89.0) | 73.0 ± 5.7 (63.5 – 84.7) | 0.071 | 0.32 |
| Males, n (%) | 60 (47.6) | 27 (42.9) | 33 (52.4) | 0.285 | 0.095+ |
| Years of education, mean ± SD (range) | 16.5 ± 2.5 (12.0 – 20.0) | 16.7 ± 2.6 (12.0 – 20.0) | 16.3 ± 2.4 (12.0 – 20.0) | 0.394 | 0.15 |
| Intracranial volume, mean ± SD | 1,483,619 ± 150,782 | 1,473,510 ± 145,261 | 1,493,729 ± 156,616 | 0.454 | −0.13 |
| Total geriatric depression, mean ± SD (range) | 0.72 ± 1.1 (0 – 6) | 0.71 ± 1.0 (0 – 5) | 0.73 ± 1.2 (0 – 6) | 0.937 | −0.01 |
| Polygenic hazard score, mean ± SD (range) | 0.01 ± 0.7 (−1.5 – 2.0) | 0.09 ± 0.7 (−1.5 – 2.0) | −0.07 ± 0.6 (−1.2 – 1.8) | 0.173 | 0.24 |
| Body mass index, mean ± SD (range) | 26.9 ± 3.8 (20.0 – 36.8) | 23.9 ± 1.8 (20.0 – 26.3) | 29.9 ± 2.7 (26.4 – 36.8) | < 0.001* | −2.61 |
| Entorhinal cortex volume, mean ± SD | 3850 ± 609 | 3766 ± 581 | 3935 ± 628 | 0.118 | −0.28 |
| Hippocampal volume, mean ± SD | 7429 ± 906 | 7329 ± 833 | 7529 ± 971 | 0.218 | −0.22 |
a
Reported effect sizes are Cohen's d unless otherwise indicated. +Reported effect size is phi correlation coefficient because variable is binary.
⁎
P < 0.05.