Author response table 1. List of twelve structures of six receptors.
| GPCR | PDB code | Resolution (Å) | Ligand G protein/G protein memetic |
State | Mutation in the TM region |
|---|---|---|---|---|---|
| bRho | 1GZM | 2.7 | 11-cis-retinal (inverse agonist, covalently bound) | Inactive | No mutation |
| 3PQR | 2.9 | All-trans-retinal (agonist, covalently bound) GαCT2 (G protein peptide) |
Active | No mutation | |
| β2AR | 2RH1 | 2.4 | Carazolol (inverse agonist) | Inactive | No mutation |
| 3SN6 | 3.2 | BI-167107 (agonist) Gs (G protein) |
Active | No mutation | |
| M2R | 3UON | 3.0 | 3-quinuclidinyl-benzilate (antagonist) | Inactive | No mutation |
| 4MQS | 3.5 | Iperoxo (agonist) Nb9-8 (nanobody) |
Active | No mutation | |
| μOR | 4DKL | 2.8 | β-funaltrexamine (antagonist) | Inactive | No mutation |
| 5C1M | 2.1 | BU72 (agonist) Nb39 (nanobody) |
Active | No mutation | |
| A2AR | 3EML | 2.6 | ZM241385 (antagonist) | Inactive | No mutation |
| 5G53 | 3.4 | NECA (agonist) Mini-Gs (engineered G protein) |
Active | No mutation | |
| κOR | 4DJH | 2.9 | JDTic (antagonist) | Inactive | I135L (3×29) |
| 6B73 | 3.1 | MP1104 (agonist) Nb39 (nanobody) |
Active | I135L (3×29) |