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. 2020 Jan 6;15:17–29. doi: 10.2147/IJN.S214349

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© 2020 Hsiao et al.

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Scheme 1 — Ultra-high pressure homogenization (UHPH) was employed to formulate nanosome-encapsulated honokiol (NHNK) to improve its feasibility for intravenous therapy against mouse experimental autoimmune encephalomyelitis. Intravenous administration of NHNK, with the properties of uniformly distributed nanosize and high encapsulation efficiency, ameliorated the severity of EAE accompanied by a significant reduction of demyelination and neuroinflammation. Mechanistic investigation revealed that the unique physicochemical properties of NHNK allow it to target activated microglia and T cells in the spinal cord, offering insight into the design and development of nanosome-based therapeutic agents for inflammatory CNS diseases.