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Effect of severe food restricted (sFR) on hypothalamic ACE and ACE2 activity. Shown are enzymes activity expressed as a rated of product formation for angiotensin converting enzyme (ACE) (a) (CT, n = 7; sFR, n = 8) and ACE2 (b, c) (CT, n = 8; sFR, n = 9) in hypothalamic homogenates from CT (open circle) or sFR (closed square) or the ratio of product to substrate (c). Values are expressed as the mean ± SEM
