Table 2.
Impact of TNF-α genotypes on the risk of more severe oral mucositis after subsequent cycles of RTH
| RTH cycle | Radiation reaction grade | CC (n = 6; %) | TT or CT | p, OR [95% CI] | TT (n = 37; %) | CC or CT | p, OR [95% CI] | CT (n = 19; %) | CC or TT | p, OR [95%CI] |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0 (n = 6; 9.7%) | – | 6 (100%) |
0.736 1.673 [0.084–33.281] |
5 (83.3%) | 1 (16.7%) |
0.241 3.750 [0.411–34.230] |
1 (16.7%) | 5 (83.3%) |
0.446 2.368 [0.258–21.787] |
| 1 (n = 56; 90.3%) | 6 (10.7%) | 50 (89.3%) | 32 (57.1%) | 24 (42.9%) | 18 (32.1%) | 38 (67.9%) | ||||
| 2 | 1 (n = 36; 58%) | 2 (5.6%) | 34 (94.4%) |
0.214 3.091 [0.521–18.331] |
23 (63.9%) | 13 (36.1%) |
0.427 1.517 [0.542–4.240] |
11 (30.6%) | 25 (69.4%) |
0.930 1.051 [0.353–3.128] |
| 2 (n = 26; 42%) | 4 (15.4%) | 22 (84.6%) | 14 (53.8%) | 12 (46.2%) | 8 (30.8%) | 18 (69.2%) | ||||
| 3 | 1 (n = 21; 33.9%) | 1 (4.8%) | 20 (95.2%) |
0.366 2.778 [0.303–25.463] |
14 (66.6%) | 7 (33.3%) |
0.424 1.565 [0.523–4.689] |
6 (28.6%) | 15 (71.4%) |
0.800 1.161 [0.367–3.676] |
| 2 and 3 (n = 41; 66.1%) | 5 (12.2%) | 36 (87.8%) | 23 (56.1%) | 18 (43.9%) | 13 (31.7%) | 28 (68.3%) | ||||
| 1 and 2 (n = 55; 88.7%) | 5 (%) | 50 (%) |
0.664 1.667 [0.166–16.758] |
35 (63.6%) | 20 (36.4%) |
0.094 4.374 [0.776–24.664] |
15 (27.3%) | 40 (72.7%) |
0.123 3.556 [0.711–17.793] |
|
| 3 (n = 7; 11.3%) | 1 (9.1%) | 6 (90.9%) | 2 (28.6%) | 5 (71.4%) | 4 (57.1%) | 3 (42.9%) | ||||
| 4 | 1 (n = 11; 17.7%) | – | 11 (100%) |
0.429 3.286 [0.172–62.673] |
9 (81.8%) | 2 (18.2%) |
0.116 3.696 [0.725–18.837] |
2 (18.2%) | 9 (81.8%) |
0.332 2.250 [0.437–11.589] |
| 2 and 3 (n = 51; 82.3%) | 6 (11.8%) | 45 (88.2%) | 28 (64.9%) | 23 (45.1%) | 17 (33.3%) | 34 (66.7%) | ||||
| 1 and 2 (n = 49; 79%) | 4 (8.2%) | 45 (91.8%) |
0.441 2.045 [0.331–12.636] |
32 (65.3%) | 17 (34.7%) |
0.090 3.012 [0.852–10.647] |
13 (26.5%) | 36 (73.5%) |
0.179 2.374 [0.672–8.380] |
|
| 3 (n = 13; 21%) | 2 (15.4%) | 11 (84.6%) | 5 (38.5%) | 8 (61.5%) | 6 (46.2%) | 7 (53.8%) | ||||
| 5 | 1 (n = 6; 9.7%) | – | 6 (100%) |
0.736 1.673 [0.084–33.281] |
6 (100%) | – |
0.115 10.524 [0.566–195.81] |
– | 6 (100%) |
0.200 6.760 [0.362–126.36] |
| 2 and 3 (n = 56; 90.3%) | 6 (10.7%) | 50 (89.3%) | 31 (65.4%) | 25 (44.6%) | 19 (33.9%) | 37 (66.1%) | ||||
| 1 and 2 (n = 48; 77.4%) | 4 (8.3%) | 44 (91.7%) |
0.512 1.833 [0.299–11.241] |
31 (64.6%) | 17 (35.4%) |
0.151 2.431 [0.723–8.175] |
13 (27.1%) | 35 (72.9%) |
0.265 2.019 [0.587–6.944] |
|
| 3 (n = 14; 22.6%) | 2 (14.3%) | 12 (85.7%) | 6 (42.9%) | 8 (57.1%) | 6 (42.9%) | 8 (57.1%) | ||||
| 6 | 1 (n = 7; 11.3%) | – | 7 (100%) |
0.655 1.970 [0.100–38.673] |
7 (100%) | – |
0.089 12.541 [0.683–230.37] |
– | 7 (100%) |
0.162 8.014 [0.434–147.85] |
| 2 and 3 (n = 55; 88.7%) | 6 (10.9%) | 49 (89.1%) | 30 (54.5%) | 25 (45.5%) | 19 (34.5%) | 36 (65.5%) | ||||
| 1 and 2 (n = 46; 74.2%) | 2 (4.3%) | 44 (95.7%) |
0.031* 7.333 [1.196–44.965] |
28 (60.9%) | 18 (39.1%) |
0.746 1.210 [0.283–3.827] |
16 (34.8%) | 30 (65.2%) |
0.239 2.311 [0.573–9.319] |
|
| 3 (n = 16; 25.8%) | 4 (25%) | 12 (75%) | 9 (56.2%) | 7 (43.8%) | 3 (18.8%) | 13 (81.2%) | ||||
| 7 | 1 (n = 8; 12.9%) | – | 8 (100%) |
0.587 2.278 [0.117–44.294] |
8 (100%) | – |
0.069 14.695 [0.808–267.35] |
– | 8 (100%) |
0.132 9.338 [0.511–170.60] |
| 2 and 3 (n = 54; 87.1%) | 6 (11.1%) | 48 (88.9%) | 29 (53.7%) | 25 (46.3%) | 19 (35.2%) | 35 (64.8%) | ||||
| 1 and 2 (n = 36; 58.1%) | – | 36 (100%) |
0.035* 23.146 [1.240–432.14] |
28 (77.8%) | 8 (22.2%) |
0.001* 6.611 [2.142–20.405] |
8 (22.2%) | 28 (77.8%) |
0.100 2.567 [0.849–7.755] |
|
| 3 (n = 26; 41.9%) | 6 (23.1%) | 20 (76.9%) | 9 (34.6%) | 17 (65.4%) | 11 (42.3%) | 15 (57.7%) |
OR odds ratio, 95% CI 95% confidence interval, *Statistically significant values