Table 3.
ROC curve analysis in the evaluation of the usefulness of TNF-α plasma concentration measurements in the detection of a higher grade of oral mucositis after subsequent cycles of RTH
| RTH cycle | Radiation reaction grade | n (%) | Cut-off | Sensitivity | Specificity | AUC [95% CI] | p |
|---|---|---|---|---|---|---|---|
| 1 | 0 | 6 (9.7%) | 7.68 | 94.3% | 33.3% |
0.593 [0.457–0.719] |
0.514 |
| 1 | 56 (90.3%) | ||||||
| 2 | 1 | 36 (58%) | 11.6 | 20% | 100% |
0.526 [0.393–0.657] |
0.738 |
| 2 | 26 (42%) | ||||||
| 3 | 1 | 21 (33.9%) | 9.5 | 50% | 71.4% |
0.528 [0.393–0.657] |
0.729 |
| 2 and 3 | 41 (66.1%) | ||||||
| 1 and 2 | 55 (88.7%) | 9.5 | 80% | 58.2% |
0.545 [0.412–0.675] |
0.735 | |
| 3 | 7 (11.3%) | ||||||
| 4 | 1 | 11 (17.7%) | 10.7 | 31.2% | 90.2% |
0.588 [0.452–0.715] |
0.341 |
| 2 and 3 | 51 (82.3%) | ||||||
| 1 and 2 | 49 (79%) | 11.6 | 33.3% | 97.9% |
0.646 [0.511–0.766] |
0.146 | |
| 3 | 13 (21%) | ||||||
| 5 | 1 | 6 (9.7%) | 10.7 | 30.2% | 100% |
0.572 [0.437–0.700] |
0.595 |
| 2 and 3 | 56 (90.3%) | ||||||
| 1 and 2 | 48 (77.4%) | 10.54 | 61.5% | 81.4% |
0.713 [0.579–0.824] |
0.018* | |
| 3 | 14 (22.6%) | ||||||
| 6 | 1 | 7 (11.3%) | 10.7 | 30.2% | 100% |
0.572 [0.437–0.700] |
0.595 |
| 2 and 3 | 55 (88.7%) | ||||||
| 1 and 2 | 46 (74.2%) | 9.08 | 57.1% | 68.9% |
0.543 [0.408–0.673] |
0.654 | |
| 3 | 16 (25.8%) | ||||||
| 7 | 1 | 8 (12.9%) | 10.67 | 31% | 89.8% |
0.517 [0.383–0.649] |
0.899 |
| 2 and 3 | 54 (87.1%) | ||||||
| 1 and 2 | 36 (58.1%) | 10.08 | 56.5% | 70.6% |
0.653 [0.515–0.774] |
0.046* | |
| 3 | 26 (41.9%) |
AUC area under curve, 95% CI 95% confidence interval, *Statistically significant values