Fig. 3.
Left ventricular haemodynamics and organ weights obtained 6 weeks after sham or transverse aortic constriction (TAC). a Heart rate, b LV end-systolic pressure, c LV end-diastolic pressure, d isovolumetric constant of relaxation, tau, as a measure of relaxation, e the rate of pressure rise maximum (dP/dtmax) as a measure of contractility, f dP/dtmax during IV infusion with dobutamine at 16 ng/g BW/min as a measure of contractile reserve. Organ weights were obtained post-mortem and normalised to tibial length for g left ventricle, h right ventricle and i lung weight. Directional changes for all parameters are consistent with severe LV hypertrophy and subsequent development of a heart failure phenotype in TAC animals, which was not affected by genetic modification. Data shown are mean ± standard error for WT-Sham n = 10, OE-Sham n = 12, WT-TAC n = 14; OE-TAC n = 19. Analysis by one-way ANOVA with Sidek’s multiple comparison test, except for data shown in panels b, f, h, and i, which failed the normality test and were analysed by Kruskal–Wallis with Dunn’s correction