Table 1. The overview of clinical features and treatment outcomes in 12 immunocompromised patients with infections among HTLV-1 carriers and ATL cases.
| Case | Age | Sex | Clinical subtype | Opportunistic infection | Onset of opportunistic infection | βD Glucan (PB) | CM V C7 HRP (PB) | Aspergillus antigen (PB) | Cryptococcus antigen (PB) | The histological Findings (BALF or TBLB) | PS | SOFA | HTLV-1 clonality | Treatment for opportunistic infection | Outcome of opportunistic infection at 28 days | Outcome of ATL at 28 days | Relapse of ATL | Salvage therapy | Final outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 34 | M | acute type | Pneumocystis pneumonia | During treatment (LSG 15, PD status) | 1278 | Negative | negative | negative | Grocott stain+ Pneumocystis PCR+ | 3 | 13 | Monoclonality | ST, Pentamidine, mPSL | Not improved (4 days) | PD | - | not done | Dead (4 days) |
| 2 | 71 | F | carrier type | Pneumocystis pneumonia | Initial diagnosis | 117 | negative | negative | negative | Grocott stain+ Pneumocystis PCR+ | 3 | 6 | n.e. | ST, Pentamidine, mPSL | Not improved (27 days) | SD | - | not done | Dead (27 days) |
| 3 | 65 | M | chronic type | Cryptococcus pneumonia | Initial diagnosis | negative | negative | negative | positive | Grocott stain+ Cryptococcal organism+ | 3 | 10 | Monoclonality | L-AMPH-B | Improved (55 days needed to remission) | SD | Relapse at 226 days | CHOP | Dead (305 days) |
| 4 | 73 | F | acute type | Aspergillus pneumonia | Initial diagnosis | negative | 4 | 2.2 | negative | Grocott stain+ Aspergillus bundles, PCR+ | 3 | 8 | Monoclonality | L-AMPH-B | Not improved (26 days) | PD | - | not done | Dead (26 days) |
| 5 | 74 | F | smoldering type | Cryptococcus pneumonia | Initial diagnosis | negative | negative | negative | positive | Grocott stain+ Cryptococcal organism+ | 0 | 0 | Clonality (-) | Surgery FLCZ | Improved (16 days needed to remission) | SD | - | not done | Alive (2689 days) |
| 6 | 56 | F | acute type | CMV pneumonia | During treatment (CHOP-VMMV, PD status) | 18 | 1132 | negative | negative | CMV PCR+ | 3 | 6 | Biclonality | DHPG mPSL | Improved (52 days needed to remission) | CR | Relapse at 213 days | RTx | Dead (240 days) |
| 7 | 67 | M | acute type | CMV pneumonia | During treatment (CHOP-VMMV, PD status) | negative | 124 | negative | negative | CMV PCR+ | 1 | 8 | Monoclonality | DHPG mPSL | Improved (51 days needed to remission) | PR | Relapse at 133 days | CHOP | Dead (246 days) |
| 8 | 78 | F | chronic type | CMV pneumonia | Initial diagnosis | negative | 360 | negative | negative | CMV PCR+ | 0 | 6 | Monoclonality | DHPG mPSL | Not improved (14 days) | SD | - | not done | Dead (14 days) |
| 9 | 74 | M | acute type | CMV pneumonia | Initial diagnosis | negative | 121 | negative | negative | CMV PCR+ | 4 | 8 | Monoclonality | DHPG mPSL | Not improved (15 days) | PD | - | not done | Dead (15 days) |
| 10 | 72 | F | carrier | CMV pneumonia | Initial diagnosis | negative | 520 | negative | negative | CMV PCR+ | 4 | 10 | Clonality (-) | DHPG mPSL | Not improved (2 days) | SD | - | not done | Dead (2 days) |
| 11 | 54 | M | chronic type | Pneumocystis pneumonia | Initial diagnosis | 353 | negative | negative | negative | Grocott stain+ Pneumocystis PCR+ | 2 | 2 | Monoclonality | ST, mPSL | Improved (18 days needed to remission) | PR | Relapse at 153 days | mLSG 15 →allo- HSCT | Alive (631 days) |
| 12 | 78 | M | smoldering type | Pneumocystis pneumonia | Initial diagnosis | 374 | negative | negative | negative | Grocott stain+ Pneumocystis PCR+ | 2 | 3 | Monoclonality | ST, mPSL | Improved (29 days needed to remission) | SD | Relapse at 194 days | BSC | Dead (215 days) |