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. 2020 Jan 10;11:220. doi: 10.1038/s41467-019-14046-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Experimental setup for the MYC-ON mice. b Representative liver images of MYC-OFF or MYC-ON mice treated with DMSO, GCA, or BFA. c, d Liver surface tumor counts (c) and survival curves (d) of mice with the indicated treatments (n = 15 mice each group; ***p < 0.001, t-test; pooled two independent experiments). e Representative liver images of MYC-ON/Axin2-CreER/Arf1^f/+ or MYC-ON/Axin2-CreER/Arf1^f/f mice. f Liver surface tumor counts of e (n = 8 mice each group; ***p < 0.001, t-test; polled repeat two independent times). g–i Arf1 inhibition induces the expression of CD8 and CD4 in the liver of MYC-ON liver tumor mice (n = 13 mice each group; ***p < 0.001, t-test; polled repeat three independent times). j Arf1 inhibition induces the expression of MHC-I and MHC II in the liver of MYC-ON liver tumor mice (n = 13 mice each group; ***p < 0.001, t-test; polled repeat three independent times). Data are shown as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t-test. Scale bars are as indicated.