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. 2020 Jan 10;10:142. doi: 10.1038/s41598-019-56705-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Behaviour of a cell in an electric field. (a) At low frequencies, the cell membrane constitutes a significant barrier to the current flow and information about the cell size is gained. (b) At intermediate frequencies, information of the membrane properties is revealed. (c) At high frequencies, the current can cross the cell membrane providing information about the cell interior. (Figure adapted and used with permission from Amphasys AG²⁰).