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. 2020 Jan 10;11(1):22. doi: 10.1038/s41419-019-2215-8

Fig. 1. PARP-1 deletion attenuates diabetic atherosclerotic calcification.

Fig. 1

a, b PARP-1 deletion decreased Alizarin Red positively stained atherosclerotic lesion area in diabetic ApoE−/− mice. c, d PARP-1 deletion decreased aortic calcium content and pulse wave velocity. Arrows indicate calcium mineral deposition. e, f Immunohistochemical staining shows increased Runx2-positive areas in diabetic ApoE−/− mice. g Real-time PCR shows increased Runx2 gene expression in the aortas of diabetic ApoE−/− mice. Scale bar = 100 µm. Bar values represent the means ± SD. n = 8 in each group. Asterisks indicate statistically significant differences (*P < 0.01, vs. ApoE−/− HFD mice). The statistical tests are justified as appropriate and meet the assumptions of the tests. The variance between the groups is similar.