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. 2020 Jan 10;11(1):22. doi: 10.1038/s41419-019-2215-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Predicted Stat1 binding site (underlined) within the human Runx2 promoter. Mutants with deletion of the predicted binding site (Runx2-mut1, Runx2-mut2, and Runx2-mut3) are shown. b Luciferase activity assay was performed after transfection with the human Runx2 promoter or Runx2 promoter mutants in 293T cells (n = 5).*P < 0.01, vs. transfection with con siRNA. c ChIP assay to verify binding of Stat1 to the Runx2 promoter (n = 5). The statistical tests are justified as appropriate and meet the assumptions of the tests. The variance between the groups is similar.