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. 2020 Jan 10;10:126. doi: 10.1038/s41598-019-57022-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental setup. (A) Photo of chronic eye infusion system. (B) Schematic of system components. Rat eye is implanted with a fine cannula (a) that is connected, via a head-mounted plastic coupler (b) and flexible tubing that runs inside a metal spring (c), to a rotary swivel (d). The swivel connects the tubing to a pressure sensor (e) and a variable-height reservoir of AAH (g) via a 3-way stopcock (f). Dashed line indicates that the sensor is positioned at rat eye level. (C) Photo of the head-mounted coupler. (D) Schematic of coupler components. Bone screws and cement affix the coupler to the skull. A metal L-shaped stent inside the coupler connects the implanted cannula to external tubing, and a metal spring attached to the coupler protects the tubing from animal bites.