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. 2020 Jan 10;10:126. doi: 10.1038/s41598-019-57022-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IOP-induced loss of RGCs. (A) Fraction of surviving cells as a function of the duration of IOP elevation and cumulative IOP insult. Survival fraction (SF) was defined as the ratio of RGC counts in the implanted and non-implanted eyes. Points at 0 days are control animals in which a cannula was implanted for several weeks but IOP was not elevated. Solid line is a regression of the data to the equation: $S F = 1 - b (1 - e^{- a t})$ . (B) Average RGC count (top) and density (bottom) in non-implanted and implanted eyes exposed to 0 weeks (controls) and approximately 2, 4, and 9 weeks of IOP elevation. Symbols give individual eye data. Error bars are standard deviations. Asterisks indicate statistically significant differences.