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. 2020 Jan 10;10:126. doi: 10.1038/s41598-019-57022-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regional variation in RGC loss. (A) Images of Brn3a-positive nuclei in the central (top) and peripheral (bottom) retina of the non-implanted (left) and implanted (right) eyes of an animal after 63 days of IOP elevation. Scale bar is 100 μm (B) Survival fraction of RGCs within central, inner peripheral, mid peripheral, and outer peripheral regions of the retina of animals exposed to 0 weeks (controls) and approximately 2, 4, and 9 weeks of IOP elevation. SF was computed for each region from the ratio of cell densities in the implanted and non-implanted eye. Symbols give individual eye data. Error bars give standard deviation. Asterisks indicate statistical differences from control animals.