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. 2020 Jan 10;11:215. doi: 10.1038/s41467-019-13916-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Experimental schematic of scRNAseq, performed at day 6 (following 3 days of dual-smad inhibition) and day 13 (following 7 days of specification in CBRa). b UMAP visualization of cells at days 6 and 13 of differentiation. c UMAP visualization of expression of specific endodermal (SOX17 and FOXA2), lung (NKX2-1, SOX2, and SOX9) and intestinal (CDX2) markers at days 6 and 13 of differentiation. Color scale indicates normalized log fold change of gene expression. d UMAP visualization of expression of intestinal stem cell markers LGR5, OLFM4, and TACTSTD2 (TROP2) in cells at days 6 and 13 of differentiation.