Table 3.
The relationship between the number of gene hypermethylation status and 5-year TTP of CRC patients.
| Normal tissues | Tumor tissues | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of subjects | No. of cases (%) | Crude | Adjusted | No. of subjects | No. of cases (%) | Crude | Adjusted | |||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |||||
| NO. of hypermethylation gene | ||||||||||||
| 0 | 18 | 5 (27.8) | 1.00 | Referent | 1.00 | Referent | 8 | 2 (25.0) | 1.00 | Referent | 1.00 | Referent |
| 1 | 49 | 17 (34.7) | 1.22 | (0.39 to 3.78) | 1.51 | (0.33 to 6.93) | 20 | 5 (25.0) | 0.85 | (0.16 to 4.64) | 1.24 | (0.13 to 12.0) |
| 2 | 49 | 23 (46.9) | 2.24 | (0.77 to 6.52) | 3.05 | (0.69 to 13.5) | 47 | 19 (40.4) | 1.27 | (0.28 to 5.67) | 1.84 | (0.23 to 14.5) |
| 3 | 27 | 12 (44.4) | 2.12 | (0.66 to 6.79) | 2.81 | (0.57 to 13.8) | 44 | 19 (43.2) | 1.76 | (0.40 to 7.66) | 3.00 | (0.38 to 23.6) |
| 4 | 10 | 6 (60.0) | 2.88 | (0.77 to 10.8) | 6.23 | (1.16 to 33.5) | 28 | 16 (57.1) | 2.99 | (0.69 to 13.1) | 4.12 | (0.53 to 32.5) |
| 5 | 0 | 0 (0) | N/A | N/A | N/A | N/A | 6 | 2 (33.3) | 1.47 | (0.21 to 10.4) | 3.12 | (0.26 to 36.9) |
| p for trend | 0.03 | <0.01 | 0.02 | 0.01 | ||||||||
| ≥2 of genes | 86 | 41 (47.7) | 1.97 | (1.09 to 3.56) | 2.28 | (1.17 to 4.44) | 125 | 56 (44.8) | 2.03 | (0.87 to 4.75) | 2.34 | (0.82 to 6.71) |
Abbreviations: TTP, time to progression; CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval; N/A, not applicable.
Adjusted for gender, age at surgery (continuous), adjuvant chemotherapy, histological grade and tumor location.
Not applicable due to limited numbers of cases.