Table 1.

Individual clinical characteristics and manifestations in FACAS patients.

Characteristic	Patient ID #1	Patient ID #2	Patient ID #5	Patient ID #7
Age at diagnosis	35	64	9	27
Sex	Female	Male	Female	Female
Age at disease onset	After birth	After birth	After birth	After birth
Skin symptoms	Cold-induced urticarial rash	Cold-induced urticarial rash	Cold-induced urticarial rash	Cold-induced urticarial rash
CNS symptoms	Headache	Headache	Headache	Headache
Musculo-skeletal symptoms	Moderate arthralgia	Severe arthralgia	None	Mild arthralgia
Systemic symptoms	Fatigue, subfebrile temperatures	Fatigue, subfebrile temperatures	Fatigue	Fatigue
S100 A12 in ng/ml (ref. <200)	523.7	n.a.	1024.3	n.a.
S100 A8/9 in µg/ml (ref. <2.94)	n.a.	4.10	n.a.	4.51
Serum amyloid A in mg/l (ref. <6.40)	16.80	n.a.	n.a.	8.20