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. 2020 Jan 10;11:183. doi: 10.1038/s41467-019-13919-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative images of Aβ pathology in the aBLA and pBLA by 6E10 staining. Scale bar, 100 μm. Volcano plot showing protein changes in the aBLA (b) and pBLA (d) in 6-month-old APP/PS1 versus wild-type (Wt) mice. Red and green dots represent proteins whose abundance is significantly increased or decreased. GO enrichment analysis of up- and downregulated GO categories in the aBLA (c) and pBLA (e) of APP/PS1 mice versus Wt mice, or GO categories differentially regulated in pBLA versus aBLA of APP/PS1 mice (f). n = 3 mice per group.