Table 1:

Conditioning parameters

	Males		2-way RM ANOVA	Females		2-way RM ANOVA
	Sal	Ket		SAL	Ket
Amount of chocolate consumed (mg)
Week 1	9.58 ± 2.79	14.58 ± 5.25	Treatment: F[1, 46] = 0.21; p = 0.65 Time: F[2, 92] = 8.01; p < 0.001*** Interaction: F[2, 92] = 2.13; p = 0.13	43.75 ± 8.25	45.83 ± 10.60	Treatment: F[1, 46] = 1.34; p = 0.25 Time: F[2, 92] = 15.27; p < 0.001*** Interaction: F[2, 92] = 1.77; p = 0.18
Week 3	27.50 ± 6.95	26.25 ± 10.4		97.08 ± 11.25	72.50 ± 11.46
Week 5	40.00 ± 9.38	24.17 ± 7.82		97.08 ± 15.76	71.67 ± 12.75
Latency to first approach chocolate pellets (sec)
Week 1	25.17 ± 4.09	19.86 ± 3.26	Treamentt: F[1, 46] = 0.16; p = 0.70 Time: F[2, 92] = 2.32; p = 0.10 Interaction: F[2, 92] = 0.08; p = 0.93	21.01 ± 2.49	18.00 ± 3.65	Treatmetn: F[1, 46] = 2.61; p = 0.11 Time: F[2, 86] = 1.30; p = 0.28 Interaction: F[2, 86] = 1.13; p = 0.33
Week 3	16.33 ± 3.24	17.73 ± 4.64		42.26 ± 18.57	13.88 ± 2.68
Week 5	40.64 ± 13.32	35.17 ± 18.88		22.07 ± 10.85	9.48 ± 1.94
Time spent in the center (first 5 min; sec)
Week 1	16.54 ± 1.84	15.96 ± 1.60	Treatment: F[1, 46] = 0.42; p = 0.52 Time: F[2, 92] = 19.18; p < 0.001*** Interaction: F[2, 92] = 1.42; p = 0.25	17.16 ± 1.73	15.67 ± 1.68	Treatment: F[1, 46] = 1.83; p = 0.18 Time: F[2, 92] = 3.70; p < 0.05* Interaction: F[2, 92] = 0.64; p = 0.53
Week 3	12.06 ± 1.52	8.61 ± 1.36		15.64 ± 2.26	11.38 ± 1.57
Week 5	7.99 ± 1.52	8.90 ± 1.50		14.87 ± 1.65	12.24 ± 1.65
Time spent in the center (total 60 min; sec)
Week 1	252.7 ± 24.08	267.2 ± 26.21	Treatment: F[1, 45] = 0.01; p = 0.91 Time: F[2, 90] = 1.04; p = 0.36 Interaction: F[2, 90] = 0.86; p = 0.43	284.9 ± 34.25	266.6 ± 20.55	Treatment: F[1, 43] = 0.09; p = 0.77 Time: F[2, 86] = 2.38; p = 0.1 Interaction: F[2, 86] = 0.79; p = 0.24
Week 3	244.8 ± 25.15	248.0 ± 18.32		321.1 ± 37.59	317.5 ± 23.08
Week 5	289.4 ± 35.91	256.6 ± 31.29		292.9 ± 25.64	328.4 ± 29.18

Abbreviations: Ket, ketamine; RM, repeated measures; Sal, saline