Table 1. Identification of genes associated with brain metastasis-free survival (MFS).
The top 20 upregulated genes in brain tropic tumor cells and located on the chromosome 9q amplified region were selected based on their expression change adjusted P value. Genes were analyzed for association with MFS for brain, lung and bone using data from a public dataset (GSE12276). Brain MFS P values were determined with log-rank test.
| Gene symbol | Log2foldchange brain tropic vs non brain tropic | padj | Brain MFS pvalue | MFS description |
|---|---|---|---|---|
| SEMA4D | 1.80 | 2.39e-11 | 0.0023 | decreased brain MFS |
| FAM120AOS | 1.34 | 2.41e-13 | 0.0024 | increased brain MFS |
| FAM189A2 | 5.53 | 4.13e-16 | 0.006 | increased brain MFS |
| SLC44A1 | 1.41 | 1.16e-13 | 0.0101 | increased brain MFS |
| CTSL | 2.91 | 5.52e-11 | 0.019 | decreased brain and lung MFS |
| NOL8 | 1.74 | 6.71e-11 | 0.046 | increased brain MFS |
| UBQLN1 | 1.57 | 2.95e-23 | 0.0566 | increased brain MFS |
| PHF2 | 1.29 | 4.85e-10 | 0.078 | increased brain MFS |
| FXN | 2.97 | 2.44e-17 | 0.088 | |
| CDC14B | 3.31 | 2.61e-15 | 0.1217 | |
| NAA35 | 1.23 | 1.96e-11 | 0.2351 | |
| OSTF1 | 1.38 | 1.67e-10 | 0.3012 | |
| RNF20 | 1.92 | 4.92e-21 | 0.5576 | |
| MFSD14B | 1.41 | 6.79e-10 | 0.6678 | |
| TDRD7 | 2.68 | 1.80e-14 | 0.7787 | |
| BICD2 | 1.24 | 3.00e-10 | 0.786 | |
| SLC35D2 | 1.72 | 5.39e-11 | 0.8438 | |
| TMEM245 | 1.47 | 3.52e-10 | 0.8911 | |
| SPTLC1 | 1.89 | 2.75e-31 | 0.92 | |
| C9orf64 | 1.76 | 4.94e-14 | 0.9235 |