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. Author manuscript; available in PMC: 2020 Jan 11.
Published in final edited form as: Bioorg Chem. 2019 Nov 13;94:103414. doi: 10.1016/j.bioorg.2019.103414

Fig. 5.

Fig. 5.

(a) Crystal structure of SKI-II (pink) bound to SphK1. (b) Crystal structure of SKI-II (pink) bound to SphK1 superimposed with structure of 4a (cyan) in the conformation similar to SKI-II. (c) Crystal structure of SKI-II (pink) bound to SphK1 superimposed with 4a (cyan) in the inverted conformation respect to SKI-II. (d) Crystal structure of SKI-II (pink) bound to SphK1 together with 4a (cyan) superimposed on PF-543 (orange).