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. Author manuscript; available in PMC: 2020 Jan 11.
Published in final edited form as: Bioorg Chem. 2019 Nov 13;94:103414. doi: 10.1016/j.bioorg.2019.103414

Table 6.

Synthesis of quinolone-pyperazin-pyrimidine hybrids 13–15ab.

graphic file with name nihms-1065234-t0006.jpg
Compound R1 R2 Ar Yield (%)
13a CH3O− CH3O− p-Cl-Ph- 50
13b CH3O− CH3O− naphthyl 57
14a CH3O− H p-Cl-Ph- 60
14b CH3O− H naphthyl 58
15a H H p-Cl-Ph- 55
15b H H naphthyl 52